Article
A single amino acid substitution in the NS4B protein of Dengue virus confers enhanced virus growth and fitness in human cells in vitro through IFN-dependent host response.
The Journal of general virology - 1 Aug 2018
Bui Thuy Thu, Moi Meng Ling, Nabeshima Takeshi, Takemura Taichiro, Nguyen Trang Thu, Nguyen Linh Ngoc, Pham Hang Thi Thu, Nguyen Thi Thu Thuy, Manh Dao Huy, Dumre Shyam Prakash, Mizukami Shusaku, Hirayama Kenji, Tajima Shigeru, Le Mai Thi Quynh, Aoyagi Kiyoshi, Hasebe Futoshi, Morita Kouichi
Abstract excerpt
Dengue virus (DENV) replication between mosquito and human hosts is hypothesized to be associated with viral determinants that interact in a differential manner between hosts. However, the understanding of inter-host viral determinants that drive DENV replication and growth between hosts is limited. Through the use of clinical isolates, we identified an amino acid variation of Ala, Met and Val at position 116 of...
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