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Article

A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk.

BMC cancer - 15 Jun 2018

Xiao Qin, Chen Lianzhou, Luo Haiqing, Li Hongmei, Kong Qingming, Jiao Fei, Pang Shifeng, Zhang Ming, Lan Feifei, Fan Wenguo, Luo Hui, Tao Tao, Zhu Xiao

Abstract excerpt

BACKGROUND: CHD5 is a conventional tumour-suppressing gene in many tumours. The aim of this study was to determine whether CHD5 variants contribute to the risk of hepatocellular carcinoma (HCC). METHODS: Gene variants were identified using next-generation sequencing targeted on referenced mutations followed by TaqMan genotyping in two case-control studies. RESULTS: We discovered a rare variant (haplotype AG) in...

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Identifiers

PMID: 29907144
DOI: 10.1186/s12885-018-4551-y
PMCID: PMC6003142

Genes

CHD5

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