Article
Amino acid alterations in Gag that confer the ability to grow in simian cells on HIV-1 are located at a narrow CA region.
The journal of medical investigation : JMI - 1 Feb 2009
Nagao Tamiko, Hatcho Kazuki, Doi Naoya, Fujiwara Sachi, Adachi Akio, Nomaguchi Masako
Abstract excerpt
We previously generated a prototype monkey-tropic human immunodeficiency virus type 1 (HIV-1) designated NL-DT5R. This viral clone has a small region of simian immunodeficiency virus (SIV) within Gag capsid (CA) protein and also SIV Vif protein, but displays a poor growth phenotype in simian cell...
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