Adhesion molecules and hydroxyurea in the pathophysiology of sickle cell disease

Abstract excerpt

ickle cell disease (SCD) is a systemic disorder caused by a mutation in the gene encoding the chain of hemoglobin. This mutation leads to the production of sickle hemoglobin (HbS) which is predisposed to polymerization while the hemoglobin is not oxygenated. HbS polymerization and Hb denaturation are thought to result in oxidant damage to the red blood cell membrane. Associated with such damage is abnormal...

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