Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation.

doi:10.1016/j.jaci.2018.05.026

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Article

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation.

The Journal of allergy and clinical immunology - 1 Feb 2019

Jevnikar Zala, Östling Jörgen, Ax Elisabeth, Calvén Jenny, Thörn Kristofer, Israelsson Elisabeth, Öberg Lisa, Singhania Akul, Lau Laurie C K, Wilson Susan J, Ward Jonathan A, Chauhan Anoop, Sousa Ana R, De Meulder Bertrand, Loza Matthew J, Baribaud Frédéric, Sterk Peter J, Chung Kian Fan, Sun Kai, Guo Yike, Adcock Ian M, Payne Debbie, Dahlen Barbro, Chanez Pascal, Shaw Dominick E, Krug Norbert, Hohlfeld Jens M, Sandström Thomas, Djukanovic Ratko, James Anna, Hinks Timothy S C, Howarth Peter H, Vaarala Outi, van Geest Marleen, Olsson Henric

Abstract excerpt

BACKGROUND: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthmatic patients is unclear. OBJECTIVE: We sought to explore the association between epithelial IL-6TS pathway activation and molecular and clinical phenotypes in asthmatic patients. METHODS: An IL-6TS gene signature...

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Identifiers

PMID: 29902480
DOI: 10.1016/j.jaci.2018.05.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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