Article
Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle.
American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2007
Ammit Alaina J, Moir Lyn M, Oliver Brian G, Hughes J Margaret, Alkhouri Hatem, Ge Qi, Burgess Janette K, Black Judith L, Roth Michael
Abstract excerpt
Increased levels of IL-6 are documented in asthma, but its contribution to the pathology is unknown. Asthma is characterized by airway wall thickening due to increased extracellular matrix deposition, inflammation, angiogenesis, and airway smooth muscle (ASM) mass. IL-6 binds to a specific membrane-bound receptor, IL-6 receptor-alpha (mIL-6Ralpha), and subsequently to the signaling protein gp130. Alternatively,...
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