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Wnt Signaling Pathway in Invasive Ductal Carcinoma of the Breast: Relationship between β-Catenin, Disheveled and Cyclin D1 Expression

1 Jan 2007

Abstract excerpt

OBJECTIVE: The Wnt/beta-catenin signaling cascade is an important signal transduction pathway in human cancers. Overexpression of beta-catenin and its downstream effector, cyclin D1, is implicated in malignant transformation and acquisition of an invasive tumor phenotype. This study aimed to determine the clinical significance of Wnt/beta-catenin canonical pathway components in breast cancer. METHODS: Expression...

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PMID: 18337623
DOI: 10.1159/000120999

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