Article
Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2009
Ahmad S Tariq, Sweeney Sean T, Lee Jin-A, Sweeney Neal T, Gao Fen-Biao
Abstract excerpt
Frontotemporal dementia (FTD) is the most common form of dementia before 60 years of age. Rare pathogenic mutations in CHMP2B, which encodes a component of the endosomal sorting complex required for transport (ESCRT-III), are associated with FTD linked to chromosome 3 (FTD3). Animal models of FTD3 have not yet been reported, and what signaling pathways are misregulated by mutant CHMP2B in vivo is unknown. Here we...
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