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Article

Uncoupling the Folding and Binding of an Intrinsically Disordered Protein.

Journal of molecular biology - 3 Aug 2018

Poosapati Anusha, Gregory Emily, Borcherds Wade M, Chemes Lucia B, Daughdrill Gary W

Abstract excerpt

The relationship between helical stability and binding affinity was examined for the intrinsically disordered transactivation domain of the myeloblastosis oncoprotein, c-Myb, and its ordered binding partner, KIX. A series of c-Myb mutants was designed to either increase or decrease helical stability without changing the binding interface with KIX. This included a complimentary series of A, G, P, and V mutants at...

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Identifiers

PMID: 29890118
DOI: 10.1016/j.jmb.2018.05.045
PMCID: PMC6082395

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