Evaluation of phenotypic and functional stability of RAW 264.7 cell line through serial passages.

doi:10.1371/journal.pone.0198943

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Article

Evaluation of phenotypic and functional stability of RAW 264.7 cell line through serial passages.

PloS one - 1 Jan 2018

Taciak Bartłomiej, Białasek Maciej, Braniewska Agata, Sas Zuzanna, Sawicka Paulina, Kiraga Łukasz, Rygiel Tomasz, Król Magdalena

Abstract excerpt

Established cell lines are widely used in research, however an appealing question is the comparability of the cells between various laboratories, their characteristics and stability in time. Problematic is also the cell line misidentification, genetic and phenotypic shift or Mycoplasma contamination which are often forgotten in research papers. The monocyte/macrophage-like cell line RAW 264.7 has been one of the...

Topics

Animals
Macrophages
Mice
Nitric Oxide
Phagocytosis
Phenotype
Proteins
RAW 264.7 Cells
Real-Time Polymerase Chain Reaction

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Identifiers

PMID: 29889899
DOI: 10.1371/journal.pone.0198943
PMCID: PMC5995401

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