Culture density influences the functional phenotype of human macrophages.

doi:10.3389/fimmu.2023.1078591

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Article

Culture density influences the functional phenotype of human macrophages.

Frontiers in immunology - 1 Jan 2023

Ruder Adele V, Temmerman Lieve, van Dommelen Joep M A, Nagenborg Jan, Lu Chang, Sluimer Judith C, Goossens Pieter, Biessen Erik A L

Abstract excerpt

Macrophages (MΦ) are commonly cultured in vitro as a model of their biology and functions in tissues. Recent evidence suggests MΦ to engage in quorum sensing, adapting their functions in response to cues about the proximity of neighboring cells. However, culture density is frequently overlooked in the standardization of culture protocols as well as the interpretation of results obtained in vitro. In this study,...

Topics

Humans
Inflammasomes
Macrophages
Cytokines
Phenotype
Lipids

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Identifiers

PMID: 36969194
DOI: 10.3389/fimmu.2023.1078591
PMCID: PMC10036771

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