Article
Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: a proof of concept for multivariate endophenotypes.
Translational psychiatry - 8 Jun 2018
Fan Chun Chieh, Schork Andrew J, Brown Timothy T, Spencer Barbara E, Akshoomoff Natacha, Chen Chi-Hua, Kuperman Joshua M, Hagler Donald J, Steen Vidar M, Le Hellard Stephanie, Håberg Asta Kristine, Espeseth Thomas, Andreassen Ole A, Dale Anders M, Jernigan Terry L, Halgren Eric
Abstract excerpt
Despite great interest in using magnetic resonance imaging (MRI) for studying the effects of genes on brain structure in humans, current approaches have focused almost entirely on predefined regions of interest and had limited success. Here, we used multivariate methods to define a single neuroanatomical score of how William's Syndrome (WS) brains deviate structurally from controls. The score is trained and...
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