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Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms.

Biochimica et biophysica acta. Proteins and proteomics - 1 Jan 2019

Futamura Yushi, Muroi Makoto, Aono Harumi, Kawatani Makoto, Hayashida Marina, Sekine Tomomi, Nogawa Toshihiko, Osada Hiroyuki

Abstract excerpt

Cancer cells can reprogram their metabolic machinery to survive. This altered metabolism, which is distinct from the metabolism of normal cells, is thought to be a possible target for the development of new cancer therapies. In this study, we constructed a screening system that focuses on bioenergetic profiles (specifically oxygen consumption rate and extracellular acidification rate) and characteristic proteomic...

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PMID: 29883687
DOI: 10.1016/j.bbapap.2018.06.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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