Article
Antibiotic efficacy is linked to bacterial cellular respiration.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2015
Lobritz Michael A, Belenky Peter, Porter Caroline B M, Gutierrez Arnaud, Yang Jason H, Schwarz Eric G, Dwyer Daniel J, Khalil Ahmad S, Collins James J
Abstract excerpt
Bacteriostatic and bactericidal antibiotic treatments result in two fundamentally different phenotypic outcomes--the inhibition of bacterial growth or, alternatively, cell death. Most antibiotics inhibit processes that are major consumers of cellular energy output, suggesting that antibiotic treatment may have important downstream consequences on bacterial metabolism. We hypothesized that the specific metabolic...
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