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Article

Evaluation of the detection of Toll-like receptors (TLRs) in cancer development and progression in patients with colorectal cancer.

PloS one - 1 Jan 2018

Messaritakis Ippokratis, Stogiannitsi Maria, Koulouridi Asimina, Sfakianaki Maria, Voutsina Alexandra, Sotiriou Afroditi, Athanasakis Elias, Xynos Evangelos, Mavroudis Dimitris, Tzardi Maria, Souglakos John

Abstract excerpt

BACKGROUND: Toll-like receptors (TLRs) play essential role in innate and acquired immunity, are expressed in various cell types, and are associated with altered susceptibility to many diseases, and cancers. The aim of this study was to investigate TLR2 (-196 to-174del), TLR4 (Asp299Gly and Thr399Ile) and TLR9 (T1237C and T1486C) gene polymorphisms at risk of colorectal cancer (CRC) development and progression....

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Share to Colorectal Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Restriction Fragment Length

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Source

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Identifiers

PMID: 29883450
DOI: 10.1371/journal.pone.0197327
PMCID: PMC5993256

Genes

TLR4
TLR2
TLR9
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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