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Article

Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and colorectal cancer patients with advanced stage and lymph node metastasis.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2014

Omrane Ines, Baroudi Olfa, Kourda Nadia, Bignon Yves-Jean, Uhrhammer Nancy, Desrichard Alexis, Medimegh Imen, Ayari Hager, Stambouli Nejla, Mezlini Amel, Bouzayenne Hssan, Marrakchi Raja, Benammar-Elgaaid Amel, Bougatef Karim

Abstract excerpt

Toll-like receptors (TLRs) are considered as major endotoxin-signaling receptor and as crucial sensors of innate immunity. TLRs recognize pathogen-associated molecular patterns; induce effectors genes involving inflammatory cytokines and therefore initiation of adaptative immune responses against...

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Source

Identifiers

PMID: 23949880
DOI: 10.1007/s13277-013-1075-6

Genes

TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23949880-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and colorectal cancer patients with advanced stage and lymph node metastasis.PMID 23949880Read ↗

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Evaluation of the detection of Toll-like receptors (TLRs) in cancer development and progression in patients with colorectal cancer.Semantic proximity Read ↗

Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in cancer: a meta-analysis.Semantic proximity Read ↗

Toll-Like Receptors (TLRs): Structure, Functions, Signaling, and Role of Their Polymorphisms in Colorectal Cancer Susceptibility.Semantic proximity Read ↗

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Genetic association and functional implications of TLR4 rs1927914 polymorphism on colon cancer risk.Semantic proximity Read ↗

Variant Toll-like receptor4 (Asp299Gly and Thr399Ile alleles) and Toll-like receptor2 (Arg753Gln and Arg677Trp alleles) in colorectal cancer.Semantic proximity Read ↗

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