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Article

Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and colorectal cancer patients with advanced stage and lymph node metastasis.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jan 2014

Omrane Ines, Baroudi Olfa, Kourda Nadia, Bignon Yves-Jean, Uhrhammer Nancy, Desrichard Alexis, Medimegh Imen, Ayari Hager, Stambouli Nejla, Mezlini Amel, Bouzayenne Hssan, Marrakchi Raja, Benammar-Elgaaid Amel, Bougatef Karim

Abstract excerpt

Toll-like receptors (TLRs) are considered as major endotoxin-signaling receptor and as crucial sensors of innate immunity. TLRs recognize pathogen-associated molecular patterns; induce effectors genes involving inflammatory cytokines and therefore initiation of adaptative immune responses against pathogens. Recently, it has been shown that TLRs are involved in tumor progression. In fact, increased level of TLR4...

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Source

Identifiers

PMID: 23949880
DOI: 10.1007/s13277-013-1075-6

Genes

TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Positive link between variant Toll-like receptor 4 (Asp299Gly and Thr399Ile) and colorectal cancer patients with advanced stage and lymph node metastasis.PMID 23949880Read ↗

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Evaluation of the detection of Toll-like receptors (TLRs) in cancer development and progression in patients with colorectal cancer.Semantic proximity Read ↗

Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in cancer: a meta-analysis.Semantic proximity Read ↗

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Functional polymorphisms of Toll-like receptors 2 and 4 alter the risk for colorectal carcinoma in Europeans.Semantic proximity Read ↗

Genetic association and functional implications of TLR4 rs1927914 polymorphism on colon cancer risk.Semantic proximity Read ↗

Variant Toll-like receptor4 (Asp299Gly and Thr399Ile alleles) and Toll-like receptor2 (Arg753Gln and Arg677Trp alleles) in colorectal cancer.Semantic proximity Read ↗

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