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Article

Toll-like receptor genes and their association with colon and rectal cancer development and prognosis.

International journal of cancer - 15 Jun 2012

Slattery Martha L, Herrick Jennifer S, Bondurant Kristina L, Wolff Roger K

Abstract excerpt

Toll-like receptors (TLRs) are mediators of inflammation in the gut and potentially important modulators of colon and rectal cancer risk. We use data from a population-based study of incident colon cancer cases (n = 1,555) and controls (n = 1,956) and rectal cancer cases (n = 754) and controls (n = 959). We evaluate genetic variation in TLR2 (six SNPs), TLR3 (four SNPs) and TLR4 (eight SNPs) with risk of...

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Source

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Identifiers

PMID: 21792899
DOI: 10.1002/ijc.26314
PMCID: PMC3290725

Genes

TLR3
TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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