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Assessment of Genotoxic Effects by Constructing a 3D Cellular System with Highly Sensitive Mutagenic Human-Hamster Hybrid Cells.

Chemical research in toxicology - 16 Jul 2018

Zhang Yajun, Xu Shengmin, Wu Tao, Hu Kunyu, Chen Shaopeng, Xu An, Wu Lijun

Abstract excerpt

Owing to complex microenvironmental conditions, it is challenging to reflect the actual biological responses of tissues or the body in a two-dimensional (2D) cellular system. In the present study, a low-attachment-cultivation technique was employed to establish a highly sensitive 3D human-hamster hybrid (AL) model to study the mutagenic effects of environmental pollutants. The results showed that the established...

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PMID: 29882401
DOI: 10.1021/acs.chemrestox.8b00069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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