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Article

Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury.

European archives of psychiatry and clinical neuroscience - 1 Mar 2020

Fang Xi, Yang Chun, Li Shan, Zhan Gaofeng, Zhang Jie, Huang Niannian, Du Xiangxi, Xu Hui, Hashimoto Kenji, Luo Ailin

Abstract excerpt

Although depressive symptoms including anhedonia (i.e., loss of pleasure) frequently accompany pain, little is known about the risk factors contributing to individual differences in pain-induced anhedonia. In this study, we examined if signaling of brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-receptor-kinase B (TrkB) contribute to individual differences in the development of neuropathic...

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Source

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Identifiers

PMID: 29882089
DOI: 10.1007/s00406-018-0909-z
PMCID: PMC7036057

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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