Article

BTBD9 is a novel component of IGF signaling and regulates manganese-induced dopaminergic dysfunction

2021-02-22

Abstract excerpt

Restless legs syndrome (RLS) is a common neurological disorder associated with iron deficiency and dopaminergic (DAergic) neuronal dysfunction. BTBD9 is a genetic risk factor for RLS. However, its molecular function remains largely unknown. Here, we report the interaction between BTBD9, manganese (Mn) and insulin/insulin-like growth factor (IGF) signaling in Caenorhabditis elegans , mouse Neuro2a cells and humans...

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Literature Corpus work: f15f5757-4a6b-518d-ad21-ba3927af3aa7
DOI: 10.1101/2021.02.18.431924

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