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Article

Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse.

Reproduction (Cambridge, England) - 1 Aug 2018

Faraci Christine, Annis Sofia, Jin Joyce, Li Housaiyin, Khrapko Konstantin, Woods Dori C

Abstract excerpt

The mtDNA 'mutator' mouse, also called the 'POLG' mouse, is a well-characterized model frequently used for studies of progeroid aging. Harboring a mutation in the proofreading domain of the mitochondrial polymerase, polymerase-γ (Polg), POLG mice acquire mtDNA mutations at an accelerated rate. This results in premature mitochondrial dysfunction and a systemic aging phenotype. Previous work has demonstrated that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29875308
DOI: 10.1530/REP-18-0061
PMCID: PMC6074767

Genes

POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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