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Article

Role of Telomeric TRF2 in Orosphere Formation and CSC Phenotype Maintenance Through Efficient DNA Repair Pathway and its Correlation with Recurrence in OSCC.

Stem cell reviews and reports - 1 Dec 2018

Saha Arka, Roy Souvick, Kar Madhabananda, Roy Shomereeta, Thakur Shweta, Padhi SwatiShree, Akhter Yusuf, Banerjee Birendranath

Abstract excerpt

The major problem to effective treatment of oral cancer is the presence of therapy resistance. Presence of cancer stem cell in the bulk of tumor have been implicated in therapeutic resistance. In this study, we report a non-telomeric role of TRF2 in formation of oral cancer spheroids and CSC phenotype maintenance via an efficient DNA damage repair mechanism in the presence of chemotherapeutic insult. We report...

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Source

Identifiers

PMID: 29872959
DOI: 10.1007/s12015-018-9823-z

Genes

KLF4
ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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