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Article

Sox2 expression involvement in the oncogenicity and radiochemoresistance of oral cancer stem cells

24 Oct 2014

Abstract excerpt

OBJECTIVES: Sox2, a high-mobility-group DNA binding protein, is part of the key set of transcription factors that are involved in the maintenance of pluripotency and self-renewal in undifferentiated stem cells. A recent study has further suggested cancer stem cells (CSCs) are key contributors to radiochemoresistance and are responsible for oral squamous cell carcinoma (OSCC) progression. The aim of this study was...

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PMID: 25456004
DOI: 10.1016/j.oraloncology.2014.10.002

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