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Article

Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes

1 Jan 2018

Abstract excerpt

Transcription factors of the Sox protein family contain a DNA-binding HMG box and are key regulators of progenitor cell fate. Here, we report that expression of Sox30 is restricted to meiotic spermatocytes and postmeiotic haploids. Sox30 mutant males are sterile due to spermiogenic arrest at the early round spermatid stage. Specifically, in the absence of Sox30, proacrosomic vesicles fail to form a single...

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PMID: 29866902
DOI: 10.1242/dev.164855

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