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The effect of tau K677 lactylation on ferritinophagy and ferroptosis in Alzheimer's disease.

Free radical biology & medicine - 1 Nov 2024

An Xiaoqiong, He Jun, Xie Peng, Li Chengpeng, Xia Mingyan, Guo Dongfen, Bi Bin, Wu Gang, Xu Jianwei, Yu Wenfeng, Ren Zhenkui

Abstract excerpt

Alzheimer's disease (AD) is characterized by cognitive decline and the accumulation of amyloid-beta plaques and hyperphosphorylated tau protein. The role of tau lactylation at the K677 site in AD progression is not well understood. This study explores how tau K677 lactylation affects ferritinophagy, ferroptosis, and their functions in an AD mouse model. Results show that mutating the K677 site to R reduces tau...

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PMID: 39307193
DOI: 10.1016/j.freeradbiomed.2024.09.021

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