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Neuronal pentraxin Nptx2 regulates complement activity in the brain

2022-09-23

Abstract excerpt

Complement overactivation mediates microglial synapse elimination in neurological diseases like Alzheimer’s disease and frontotemporal dementia (FTD), but how complement activity is regulated in the brain remains largely unknown. We identified that the secreted neuronal pentraxin Nptx2 binds complement C1q and thereby regulates its activity in the brain. Nptx2-deficient mice show increased complement activity and...

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Literature Corpus work
7750033c-e4e6-5ec9-ade1-ef8ee2ac12a5
DOI
10.1101/2022.09.22.509106
Open publication

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Neuronal pentraxin Nptx2 regulates complement activity in the brainDOI 10.1101/2022.09.22.509106
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