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Article

The case for complement component 5 as a target in neurodegenerative disease

1 Feb 2023

Abstract excerpt

INTRODUCTION: Complement-based drug discovery is undergoing a renaissance, empowered by new advances in structural biology, complement biology and drug development. Certain components of the complement pathway, particularly C1q and C3, have been extensively studied in the context of neurodegenerative disease, and established as key therapeutic targets. C5 also has huge therapeutic potential in this arena, with...

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PMID: 36786123
DOI: 10.1080/14728222.2023.2177532

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