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Article

Skeletal muscle-specific Cre recombinase expression, controlled by the human α-skeletal actin promoter, improves glucose tolerance in mice fed a high-fat diet.

Diabetologia - 1 Aug 2018

Al Batran Rami, Gopal Keshav, Martin Mackenzie D, Ho Kim L, Almutairi Malak, Aburasayn Hanin, Eaton Farah, Campbell Jonathan E, Ussher John R

Abstract excerpt

AIMS/HYPOTHESIS: Cre-loxP systems are frequently used in mouse genetics as research tools for studying tissue-specific functions of numerous genes/proteins. However, the expression of Cre recombinase in a tissue-specific manner often produces undesirable changes in mouse biology that can confound data interpretation when using these tools to generate tissue-specific gene knockout mice. Our objective was to...

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PMID: 29858650
DOI: 10.1007/s00125-018-4643-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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