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Tamoxifen‐inducible Cre‐mediated recombination in adipocytes

16 Aug 2010

Abstract excerpt

To generate a mouse line which allows inducible, Cre/loxP-dependent recombination in adipocytes, we used RedE/RedT-mediated recombineering to insert the CreER(T)²-transgene, which encodes a fusion protein of Cre and a mutated tamoxifen-responsive estrogen receptor, into the start codon of the adipocyte-specific Adipoq gene. Adipoq encodes adiponectin, an adipokine specifically expressed in differentiated...

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PMID: 20715175
DOI: 10.1002/dvg.20665

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