Article
Metabolic syndrome in mice induced by expressing a transcriptional activator in adipose tissue.
Transgenic research - 1 Jun 2012
Zhang Liwen, Zhou Yuchen, Zhu Amber Ying, Li Xiang-qing, Mundt Steven S, Gao Ling, Lisnock JeanMarie, Hernandez Melba, Alonso-Galicia Magdalena, Springer Martin S, O'Neill Edward A, Daugherty Bruce L, Puig Oscar
Abstract excerpt
Metabolic syndrome is a combination of medical disorders that increases the risk of developing cardiovascular disease and diabetes. Constitutive overexpression of 11β-HSD1 in adipose tissue in mice leads to metabolic syndrome. In the process of generating transgenic mice overexpressing 11β-HSD1 in an inducible manner, we found a metabolic syndrome phenotype in control, transgenic mice, expressing the reverse...
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