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A novel tetracycline-responsive transgenic mouse strain for skeletal muscle-specific gene expression

27 Oct 2018

Abstract excerpt

BACKGROUND: The tetracycline-responsive system (Tet-ON/OFF) has proven to be a valuable tool for manipulating gene expression in an inducible, temporal, and tissue-specific manner. The purpose of this study was to create and characterize a new transgenic mouse strain utilizing the human skeletal muscle α-actin (HSA) promoter to drive skeletal muscle-specific expression of the reverse tetracycline transactivator...

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PMID: 30368256
DOI: 10.1186/s13395-018-0181-y

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