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Article

Cryptococcal Cell Morphology Affects Host Cell Interactions and Pathogenicity

17 Jun 2010

Abstract excerpt

Cryptococcus neoformans is a common life-threatening human fungal pathogen. The size of cryptococcal cells is typically 5 to 10 microm. Cell enlargement was observed in vivo, producing cells up to 100 microm. These morphological changes in cell size affected pathogenicity via reducing phagocytosis by host mononuclear cells, increasing resistance to oxidative and nitrosative stress, and correlated with reduced...

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PMID: 20585559
DOI: 10.1371/journal.ppat.1000953

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