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Article

SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s Disease

25 May 2018

Abstract excerpt

Alzheimer's Disease (AD) is the most common cause of dementia in the elderly. Centenarians - reaching the age of >100 years while maintaining good cognitive skills - seemingly have unique biological features allowing healthy aging and protection from dementia. Here, we studied the expression of SIRT1 along with miR-132 and miR-212, two microRNAs known to regulate SIRT1, in lymphoblastoid cell lines (LCLs) from 45...

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PMID: 29855513
DOI: 10.1038/s41598-018-26547-6

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