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Article

MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα.

Cellular & molecular immunology - 1 May 2019

Jaiswal Anant, Reddy Sukka Santosh, Maurya Mohita, Maurya Preeti, Barthwal Manoj Kumar

Abstract excerpt

In human adipose tissue and obesity, miR-99a expression is negatively correlated with inflammation. Therefore, the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation. M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and M1 phenotypes. Phenotype-switching experiments established an association between upregulated...

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Share to Adipose Tissue
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Mice, Mutant Strains

Share to RNA, Small Interfering

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Source

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Identifiers

PMID: 29849090
DOI: 10.1038/s41423-018-0038-7
PMCID: PMC6474300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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