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Article

Identifying Circulating Tumor DNA Mutation Profiles in Metastatic Breast Cancer Patients with Multiline Resistance.

EBioMedicine - 1 Jun 2018

Hu Zhe-Yu, Xie Ning, Tian Can, Yang Xiaohong, Liu Liping, Li Jing, Xiao Huawu, Wu Hui, Lu Jun, Gao Jianxiang, Hu Xuming, Cao Min, Shui Zhengrong, Xiao Mengjia, Tang Yu, He Qiongzhi, Chang Lianpeng, Xia Xuefeng, Yi Xin, Liao Qianjin, Ouyang Quchang

Abstract excerpt

PURPOSE: In cancer patients, tumor gene mutations contribute to drug resistance and treatment failure. In patients with metastatic breast cancer (MBC), these mutations increase after multiline treatment, thereby decreasing treatment efficiency. The aim of this study was to evaluate gene mutation patterns in MBC patients to predict drug resistance and disease progression. METHOD: A total of 68 MBC patients who had...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29807833
DOI: 10.1016/j.ebiom.2018.05.015
PMCID: PMC6020712

Genes

ERBB2
FAT1
BRCA1
MED12
NOTCH2
NOTCH4
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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