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Article

The circulating tumor DNA (ctDNA) alteration level predicts therapeutic response in metastatic breast cancer: Novel prognostic indexes based on ctDNA.

Breast (Edinburgh, Scotland) - 1 Oct 2022

Liu Binliang, Hu Zheyu, Ran Jialu, Xie Ning, Tian Can, Tang Yu, Ouyang Quchang

Abstract excerpt

PURPOSE: Circulating tumor DNA (ctDNA) has good clinical guiding value for metastatic breast cancer (MBC) patients. This study aimed to apply a novel genetic analysis approach for therapeutic prediction based on ctDNA alterations. METHOD: This nonrandomized, multicenter study recruited 223 MBC patients (NCT05079074). Plasma samples were collected for target-capture deep sequencing of ctDNA at baseline, after the...

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Identifiers

PMID: 35926241
DOI: 10.1016/j.breast.2022.07.010
PMCID: PMC9356206

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