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Article

Significant impact of circulating tumour DNA mutations on survival in metastatic breast cancer patients.

Scientific reports - 24 Mar 2021

Muendlein Axel, Geiger Kathrin, Gaenger Stella, Dechow Tobias, Nonnenbroich Christoph, Leiherer Andreas, Drexel Heinz, Gaumann Andreas, Jagla Wolfgang, Winder Thomas, Mayer Frank, Decker Thomas

Abstract excerpt

Mutational analysis of circulating tumour (ct) DNA holds promise as an effective tool to predict the course of metastatic breast cancer (MBC). In the present study we used targeted next generation sequencing of ctDNA to evaluate the impact of cancer driven mutations on the prognosis of MBC. The study included 59 oestrogen receptor-positive (ER+), HER2-negative MBC patients. Sequencing analysis was performed in...

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Identifiers

PMID: 33762647
DOI: 10.1038/s41598-021-86238-7
PMCID: PMC7990915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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