Article
Synthetic lethal interaction of the mitochondrial phosphatidylethanolamine and cardiolipin biosynthetic pathways in Saccharomyces cerevisiae.
The Journal of biological chemistry - 21 Oct 2005
Gohil Vishal M, Thompson Morgan N, Greenberg Miriam L
Abstract excerpt
Saccharomyces cerevisiae mitochondria contain enzymes required for synthesis of the phospholipids cardiolipin (CL) and phosphatidylethanolamine (PE), which are enriched in mitochondrial membranes. Previous studies indicated that PE may compensate for the lack of CL, and vice versa. These data suggest that PE and CL have overlapping functions and that the absence of both lipids may be lethal. To address this...
Topics
- Carboxy-Lyases
- Cardiolipins
- Cell Proliferation
- Cell Survival
- DNA Primers
- Endoplasmic Reticulum
- Gene Deletion
- Gene Expression Regulation, Fungal
- Golgi Apparatus
- Lipids
- Membrane Proteins
- Mitochondria
- Models, Biological