Article
Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q synthesis.
Archives of biochemistry and biophysics - 1 Aug 2001
Belogrudov G I, Lee P T, Jonassen T, Hsu A Y, Gin P, Clarke C F
Abstract excerpt
The COQ4 gene coding for a component of the coenzyme Q biosynthetic pathway in the yeast Saccharomyces cerevisiae was cloned by a functional complementation of a Q-deficient mutant strain. Yeast coq4 mutant strains harboring the COQ4 gene on either single- or multicopy plasmids acquired the ability to grow on media containing a nonfermentable carbon source, synthesize Q(6), and respire. COQ4 encodes a polypeptide...
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