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Article

Induction of quiescence (G0) in bone marrow stromal stem cells enhances their stem cell characteristics

17 May 2018

Abstract excerpt

Several studies have suggested that bone marrow stromal steam cells (BMSC) exist in a quiescent state (G0) within the in vivo niche; however, an explicit analysis of the biology of G0 state-BMSC has not been reported. We hypothesized that induction of G0 in BMSC might enhance their stem cell properties. Thus, we induced quiescence in BMSC in vitro by (a) suspension culture in a viscous medium or (b) culture on...

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PMID: 29803144
DOI: 10.1016/j.scr.2018.05.010

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