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Three stepwise pH progressions in stratum corneum for homeostatic maintenance of the skin

15 May 2024

Abstract excerpt

The stratum corneum is the outermost skin layer with a vital role in skin barrier function. It is comprised of dead keratinocytes (corneocytes) and is known to maintain its thickness by shedding cells, although, the precise mechanisms that safeguard stratum corneum maturation and homeostasis remain unclear. Previous ex vivo studies have suggested a neutral-to-acidic pH gradient in the stratum corneum. Here, we...

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PMID: 38750035
DOI: 10.1038/s41467-024-48226-z

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