Article
Redox regulation in human melanocytes and melanoma.
Pigment cell research - 1 Jun 2001
Meyskens F L, Farmer P, Fruehauf J P
Abstract excerpt
The human melanocyte is continuously exposed to intrinsic and extrinsic sources of reactive biochemical species, but is finely tuned via the intrinsic anti-oxidant and radical properties of melanin to suppress the build-up of an altered redox phenotype. We propose that this control is lost during melanomagenesis and inappropriate redox-sensitive transcriptional factor activations occur which result in enhancement...
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