Article
Phenotypic characterization of aberrant stem and progenitor cell populations in myelodysplastic syndromes.
PloS one - 1 Jan 2018
Ostendorf Benjamin N, Flenner Eva, Flörcken Anne, Westermann Jörg
Abstract excerpt
Recent reports have revealed myelodysplastic syndromes (MDS) to arise from cancer stem cells phenotypically similar to physiological hematopoietic stem cells. Myelodysplastic hematopoiesis maintains a hierarchical organization, but the proportion of several hematopoietic compartments is skewed and multiple surface markers are aberrantly expressed. These aberrant antigen expression patterns hold diagnostic and...
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