MDS: A Stem Cell Disorder—But What Exactly Is Wrong with the Primitive Hematopoietic Cells in This Disease?

Abstract excerpt

Despite the various abnormalities identified in the immune system or the bone marrow microenvironment in patients with myelodysplastic syndrome (MDS), most of the investigation of this disorder has centered on the hematopoietic stem/progenitor compartment. It is generally written that MDS is a stem cell disorder, and there is certainly evidence supporting this view. However, whether it occurs in a cell with only...

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