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Article

Loss of hematopoietic progenitors heterogeneity is an adverse prognostic factor in lower-risk myelodysplastic neoplasms.

Leukemia - 1 May 2024

Dussiau Charles, Comont Thibault, Knosp Camille, Vergnolle Inès, Bravetti Clotilde, Canali Alban, Houvert Amandine, Largeaud Laetitia, Daveaux Christian, Zaroili Laila, Friedrich Chloé, Boussaid Ismaël, Zalmai Loria, Almire Carole, Rauzy Odile, Willems Lise, Birsen Rudy, Bouscary Didier, Fontenay Michaela, Kosmider Olivier, Chapuis Nicolas, Vergez François

Abstract excerpt

Myelodysplastic neoplasms (MDS) are characterized by clonal evolution starting from the compartment of hematopoietic stem and progenitors cells (HSPCs), leading in some cases to leukemic transformation. We hypothesized that deciphering the diversity of the HSPCs compartment may allow for the early detection of an emergent sub-clone that drives disease progression. Deep analysis of HSPCs repartition by...

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Identifiers

PMID: 38575672
DOI: 10.1038/s41375-024-02234-6
PMCID: PMC11073965

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CD34
CD38

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