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Article

The myelodysplastic syndrome as a prototypical epigenetic disease

9 May 2013

Abstract excerpt

The myelodysplastic syndrome (MDS) is a clonal disorder characterized by increased stem cell proliferation coupled with aberrant differentiation resulting in a high rate of apoptosis and eventual symptoms related to bone marrow failure. Cellular differentiation is an epigenetic process that requires specific and highly ordered DNA methylation and histone modification programs. Aberrant differentiation in MDS can...

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PMID: 23660859
DOI: 10.1182/blood-2013-02-451757

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