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Molecular pathways in myelodysplastic syndromes and acute myeloid leukemia: relationships and distinctions-a review.

British journal of haematology - 1 Sept 2008

Bernasconi Paolo

Abstract excerpt

The myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are both hematopoietic stem cell disorders. However, while leukemic stem cells have been revealed by clonal tracking experiments, dysplastic stem cells have never been demonstrated by xeno-transplantation assays because of poor engraftment problems. These engraftment difficulties may be due to the unique nature of MDS genetic lesions that are...

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Identifiers

PMID: 18540941
DOI: 10.1111/j.1365-2141.2008.07245.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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