Article
Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.
British journal of cancer - 1 Jun 2018
Neumeyer Sonja, Banbury Barbara L, Arndt Volker, Berndt Sonja I, Bezieau Stephane, Bien Stephanie A, Buchanan Dan D, Butterbach Katja, Caan Bette J, Campbell Peter T, Casey Graham, Chan Andrew T, Chanock Stephen J, Dai James Y, Gallinger Steven, Giovannucci Edward L, Giles Graham G, Grady William M, Hampe Jochen, Hoffmeister Michael, Hopper John L, Hsu Li, Jenkins Mark A, Joshi Amit, Larsson Susanna C, Le Marchand Loic, Lindblom Annika, Moreno Victor, Lemire Mathieu, Li Li, Lin Yi, Offit Kenneth, Newcomb Polly A, Pharaoh Paul D, Potter John D, Qi Lihong, Rennert Gad, Schafmayer Clemens, Schoen Robert E, Slattery Martha L, Song Mingyang, Ulrich Cornelia M, Win Aung K, White Emily, Wolk Alicja, Woods Michael O, Wu Anna H, Gruber Stephen B, Brenner Hermann, Peters Ulrike, Chang-Claude Jenny
Abstract excerpt
BACKGROUND: Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findings on endogenous oestrogen exposure and CRC are inconsistent. METHODS: We used a Mendelian randomisation approach to test for a causal effect of age at menarche and age at menopause as...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.