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Article

ABCG2 Polymorphism rs2231142 and hypothyroidism in metastatic renal cell carcinoma patients treated with sunitinib.

Acta clinica Belgica - 1 Jun 2019

Werbrouck Emilie, Bastin Julie, Lambrechts Diether, Verbiest Annelies, Van Brussel Thomas, Lerut Evelyne, Machiels Jean-Pascal, Verschaeve Vincent, Richard Vincent, Debruyne Philip R, Decallonne Brigitte, Schöffski Patrick, Bechter Oliver, Wolter Pascal, Beuselinck Benoit

Abstract excerpt

BACKGROUND AND AIM: Vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) cause significant adverse events including thyroid dysfunction, mainly hypothyroidism, in a considerable proportion of patients. In a series of metastatic renal cell carcinoma (mRCC) patients treated with sunitinib, we aimed to study the correlation between hypothyroidism and single nucleotide polymorphisms...

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Share to Antineoplastic Agents
Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Renal Cell

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Source

Identifiers

PMID: 29792121
DOI: 10.1080/17843286.2018.1477229

Genes

ABCG2
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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