Article
Association Study of a Functional Variant on ABCG2 Gene with Sunitinib-Induced Severe Adverse Drug Reaction.
PloS one - 1 Jan 2016
Low Siew-Kee, Fukunaga Koya, Takahashi Atsushi, Matsuda Koichi, Hongo Fumiya, Nakanishi Hiroyuki, Kitamura Hiroshi, Inoue Takamitsu, Kato Yoichiro, Tomita Yoshihiko, Fukasawa Satoshi, Tanaka Tomoaki, Nishimura Kazuo, Uemura Hirotsugu, Hara Isao, Fujisawa Masato, Matsuyama Hideyasu, Hashine Katsuyoshi, Tatsugami Katsunori, Enokida Hideki, Kubo Michiaki, Miki Tsuneharu, Mushiroda Taisei
Abstract excerpt
Sunitinib is a tyrosine kinase inhibitor and used as the first-line treatment for advanced renal cell carcinoma (RCC). Nevertheless, inter-individual variability of drug's toxicity was often observed among patients who received sunitinib treatment. This study is to investigate the association of a functional germline variant on ABCG2 that affects the pharmacokinetics of sunitinib with sunitinib-induced toxicity...
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